By George Sack Jr.
The explicit path to USMLE EXCELLENCE IN GENETICS
High-Yield * Illustrated * USMLE Shortcuts
You'll by no means locate a neater, extra effective, and extra targeted strategy to ace genetics and genetics-related questions about the USMLE and path examinations than the USMLE highway Map. Designed to supply greatest studying in minimal time, this absolutely up-to-date USMLE highway Map deals a concise, inventive, and well-illustrated method of getting to know genetics.
The correct way--the correct questions--the correct results
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Extra info for USMLE Road Map: Genetics
2. Trisomies account for ∼50% of all chromosome-related pregnancy losses, but most affected fetuses are lost spontaneously as pregnancy progresses; thus few individuals with somatic trisomy are seen as live births (Figure 2–11). DOWN SYNDROME CLINICAL CORRELATION • Although Down syndrome is the most frequently encountered human trisomy, liveborn affected individuals are only a fraction of those conceived (Figure 2–11). The average incidence is ∼1 in 660 live births. • Affected individuals are now reaching older ages, and attention to their care as adults is important.
The fertilized oocyte is diploid (ie, 2n; it has 46 chromosomes) with a haploid set of chromosomes from each parent; development continues by means of mitosis. E. Meiosis thus embodies two different processes contributing to separation of maternally and paternally derived information. 1. Separation of sister chromatid pairs during anaphase I is random with respect to parent of origin. 2. Crossing-over mixes fragments of maternal and paternal chromosomes. N Chapter 2: Chromosomes and Chromosomal Disorders 31 F.
The data suggest a simple polymorphism of high frequency, and the two-dimensional pKa gel findings hint that a single amino acid may be changed. Many polymorphisms have been found in this way. The novel migration pattern was described as “distinct,” implying that the antibody has good specificity but that some feature of the antigenic protein had changed (choice A). Gel preparation improves with practice and the student’s finding was consistent, eliminating choice B. No data are given that would connect the change to hair growth, and the sample is too small to draw conclusions (choice C).