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By C. Caux, B. Vanbervliet, C. Massacrier, B. Dubois, C. Dezutter-Dambuyant, D. Schmitt (auth.), Dr. Jacques Banchereau, Dr. Daniel Schmitt (eds.)

These complaints comprise the contributions of the individuals of the 3rd overseas Symposium on Dendritic Cells that was once held in Annecy, France, from June 19 to June 24, 1994. This symposium represented a follow-up of the 1st and moment foreign symposia that have been held in Japan in 1990 and within the Netherlands in 1992. Dendritic cells are antigen-presenting cells, and are present in all tissues and organs of the physique. they are often categorized into: (1) interstitial dendritic cells of the center, kidney, intestine, and lung;(2) Langerhans cells within the epidermis and mucous membranes; (3) interdigitating dendritic cells within the thymic medulla and secondary lymphoid tissue; and (4) blood dendritic cells and lymph dendritic cells (veiled cells). even supposing dendritic cells in every one of those booths are all CD45+ leukocytes that come up from the bone marrow, they might convey alterations that relate to maturation nation and microenvironment. Dendritic cells are really good antigen-presenting cells for T lymphocytes: they procedure and current antigens successfully in situ, and stimulate responses from naive and reminiscence T cells within the paracortical region of secondary lymphoid organs. contemporary proof additionally demonstrates their position in induction of tolerance. in contrast, the first and secondary B-cell follicles include follicular dendritic cells that catch and maintain intact antigen as immune complexes for lengthy classes of time. The starting place of follicular dendritic cells isn't really transparent, yet such a lot investigators think that those cells are usually not leukocytes.

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4. 5. 6. 7. 8. 9. M. Steinman, Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte-macrophage colony stimulating factor. J. Exp. Med. 176:1693-1702 (1992). K. Inaba, M. Inaba, M. Deguchi, K. Hagi, R. Yasumizu, S. M. Steinman, Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl. Acad. Sci. USA 80:3038-3042 (1993). C. Caux, C. Dezutter-Dambuyant, D.

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