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By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Contaminated Drinking Water at Camp Lejeune

Within the early Nineteen Eighties, water-supply structures at the Marine Corps Base Camp Lejeune in North Carolina have been stumbled on to be infected with the economic solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water platforms have been provided by means of the Tarawa Terrace and Hadnot aspect watertreatment crops, which served enlisted-family housing, barracks for single carrier body of workers, base administrative places of work, colleges, and leisure components. The Hadnot element water method additionally served the bottom health center and an business zone and provided water to housing at the Holcomb street water procedure (full-time until eventually 1972 and periodically thereafter). This publication examines what's identified concerning the infection of the water offers at Camp Lejeune and even if the infection will be associated with any opposed overall healthiness results in former citizens and staff on the base.

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Sample text

C Glomerulonephritis is a disease that affects kidney function. d Scleroderma is a disease resulting in abnormal growth of connective tissue. b ATSDR also has a study under way on prenatal exposure to water-supply contaminants and birth defects and childhood cancer. The specific outcomes being studied are childhood leukemia, childhood non-Hodgkin lymphoma, spina bifida, anencephaly, cleft lip, and cleft palate. These outcomes are rare, and given the number of study participants, it appears that the statistical power of this study could limit its ability to detect associations.

Epidemiologic studies provide limited/suggestive evidence of an association between inhalation exposure to solvents and neurobehavioral effects; most of the reported effects were concurrent with exposure, and there has been little study of whether neurobehavioral effects persist after exposure ends. Regarding effects on the immune system, toxicologic studies in sensitive strains of mice indicate that TCE can act as a skin sensitizer, modulate existing asthma, produce immunosuppression, and influence autoimmune diseases.

Epidemiologic studies of occupational exposure to mixed solvents showed limited/suggestive evidence of neurobehavioral effects, and toxicologic studies of TCE showed some decrements in neurobehavioral outcomes. For effects on the immune system, epidemiologic studies showed limited/suggestive evidence for an association with mixed solvent exposure for certain immunologically mediated diseases. Toxicologic studies also showed that TCE can affect the immune system, as shown by immunosuppression and worsening of preexisting autoimmune diseases.

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