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By G. Stern (auth.), Professor Dr. Franz Gerstenbrand, Dr. Werner Poewe, Dr. Gerald Stern (eds.)

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Nature 274: 897-900 Lee T, Seeman P, Hornykiewicz 0, Bilbao J, Deck J, Tourtellotte W (1981) Parkinson's disease: low density and presynaptic location of 03 dopamine receptors. Brain Res 212: 494498 Lemberger L, Crabtree R, Callaghan JT (1980) Pergolide, a potent long-acting dopamine-receptor agonist. Clin Pharmacol Ther 27: 642-651 Lieberman A, Zolfaghari M, Boal 0, Hassouri H, Vogel B, Battista A, Fuxe K, Goldstein M (1976) The antiparkinsonian efficacy of bromocriptine. Neurology (Minneap) 26: 405409 Lieberman A, Kupersmith M, Neophytides A, Casson I, Durso R, Hoo Foo S, Khayali M, Bear G, Goldstein M (1980) Long-term efficacy of bromocriptine in Parkinson disease.

1978) and of the latter type LY-141865 (Tsuruta et al. 1981). Availability of selective drugs for clinical use should help to elucidate the physiological role of the different receptor types, and their involvement in the pathology of degenerative diseases. evidence relating to dopaminergic receptors is indirect. Observations are generally made on tissues that bind, specifically, to substances that are active at dopaminergic receptors, as agonists or antagonists; it is inferred that these specific binding sites represent dopaminergic receptors.

However, without doubleblind comparisons it is not possible to draw valid conclusions. Conclusions 1. In Parkinson's disease, not only is there a degeneration of nigrostriatal dopaminergic neurons, but significant changes also occur in striatal dopaminergic receptors. 2. There is evidence of a loss of striatal 03 receptors in Parkinson's disease. 3. There seem to be at least two subgroups of parkinsonian patients with regard to the behaviour of striatal 02 receptors: (a) those with a loss of 02 receptors; and (b) those with an increase in the number of 02 receptors.

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