Download Clinical Aspects of O2 Transport and Tissue Oxygenation by M. F. Perutz (auth.), Prof. Dr. med. K. Reinhart, Prof. Dr. PDF

By M. F. Perutz (auth.), Prof. Dr. med. K. Reinhart, Prof. Dr. med. K. Eyrich (eds.)

All facets of oxygen shipping and tissue oxygenation which are correct in medical medication are coated during this monograph. specialists from easy technology in addition to scientific study offer details that improves knowing of the way to regard O2-transport disturbances in day-by-day perform. designated curiosity is focussed at the query of offer dependency of O2-uptake and its function in multi-organ failure within the severely ailing. different issues are the scientific tracking of O2-transport and O2-utilisation, oxygen toxicity, and the position of O2-radicals and the reperfusion syndrome in organ transplantation and cardiopulmonary resuscitation.

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Respir Physiol 3:1~11 Fenn WO, Rahn H, Otis AB (1946) A theoretical study of the composition of alveolar air at altitude. Am J Physiol 146:637 Haldane JS (1922) Respiration. Yale University Press, New Haven Kelman GR (1966) Digital computer subroutine for the conversion of oxygen tension into saturation. J Appl PhysioI21:1375~1376 Kelman GR (1967) Digital computer procedure for the conversion ofPC0 2 into blood CO 2 content. Respir Physiol 3:335~343 Kety S (1951) The theory and applications of the exchange of inert gas at the lungs and tissues.

B. 01 01 10 100 IODO VENTILATION-PERFUSION RATIO Fig. 4 A, B. Distribution of ventilation-perfusion ratios in a patient with asthma before (A) and after (B) the administration of isoproterenol by aerosol. Note the bimodal distribution, absence of shunt, and increase in blood flow to the lower mode after the bronchodilator. (From Wagner et al. B. West Figure 4 B shows how the distribution of ventilation-perfusion ratios was altered when the patient was given the bronchodilator isoproterenol by aerosol.

5% of the cardiac output doubles the arterial concentration of sulfur hexafluoride. These results were a surprise to us and indicate that young normal subjects are ventilating essentially all of their alveoli. When older subjects were investigated, we found that their recovered distributions of ventilation-perfusion ratios differed from those found in young people. Generally the distributions are broader, indicating that the lung is less successful in matching ventilation and blood flow. Occasionally a shoulder on the left of the blood flow distribution is seen indicating excessive amounts of blood flow to poorly ventilated lung units.

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