Download Clinical Applications of Continuous Infusion Chemotherapy by Branimir Ivan Sikic (auth.), C. Julian Rosenthal M.D., PDF

By Branimir Ivan Sikic (auth.), C. Julian Rosenthal M.D., Marvin Rotman M.D. (eds.)

The first convention on concomitant infusion chemotherapy and radia­ tion treatment was once geared up with the goal of bringing jointly many of the investigators who've demonstrated, over the past few years, the hypo­ thesis that non-stop infusion chemotherapy may perhaps modulate the cytotoxic impression of radiation remedy to the purpose of getting a strongly additive, if now not synergistic task on sure malignant tumors. This quantity represents the particular court cases of this convention offered in a manner that gives the reader a overview of the on-going re­ seek within the box. we have now under pressure a few topics from easy biologic learn and impact of mobile kinetics to the sensible equipment of drug supply structures and early scientific reviews. the reason for this new form of mixed modality remedy has been provided by means of a few of its pioneers. Early medical investigations in addition to the initial facts of many who haven't but thoroughly matured have additionally been integrated. The reader may still examine those facts with a few reser­ vations. eventually, those effects has to be proven through better potential randomized reviews with right controls earlier than changing into authorized because the remedy of selection in in the neighborhood complex tumors.

Show description

Read Online or Download Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy PDF

Best clinical books

Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application

Many pathogens and aberrant malignant cells convey specific carbohydrates on their floor representing beautiful objectives for vaccine layout. substantial development has lately been made within the id of novel carbohydrate dependent vaccines and a multitude has reached medical part experiences. The luck of a number of authorized carbohydrate established vaccines opposed to bacterial pathogens equivalent to Haemophilus influenzae style b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice strength.

Principles and Practice of Clinical Virology, Sixth Edition

Content material: bankruptcy 1 Diagnostic ways (pages 1–27): Katie Jeffery and Emma AaronsChapter 2 Viral Transmission: an infection got through the Blood? Borne direction (pages 29–41): Will IrvingChapter three Viral Transmission: an infection got via All different Routes (Respiratory, Eye–Nose–Mouth, Inoculation and Faeco?

Myocardial viability: Detection and clinical relevance

Long ago few years it has develop into transparent that left ventricular disorder, even of critical measure, can be reversible after coronary revascularization in a few sufferers. therefore, myocardial viability has captured the mind's eye of researchers and clinicians looking to get to the bottom of the mobile and subcellular mechanisms and outline applicable diagnostic modalities.

Extra resources for Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

Sample text

20. T. Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res. 41:3288-3295, 1981. 21. T. Relationship of cellular folate cofactor pools to activity of 5-fluorouracil. Mol. Pharmacol. 23:190-197, 1983. 22. M. A method for continuous drug infusion in unrestrained rats: its application in evaluating the toxicity of 5-fluorouracil/thymidine combination. J. Lab. Clin. Med. 93:1047-1053, 1979. 23. J. Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.

The only reasonable explanation is that there is a lower peak drug level, and there is time for the peak to be eliminated before the next dose. The best ,;ray to limit peak drug levels is to give a continuous infusion because the peak is inversely proportional to the time over which drug is given. We started a study, therefore, using adriamycin as a continuous infusion at a fixed dose of 60 mg/m 2 as a single agent in patients with CMF-resistant breast cancer. 16 All patients were required to have central venous catheters.

Infusion No. M. Toxicity (1) G. I. Toxicity ( 2) Ref. 30 149 pts. V. Push 20-25mg/kg 2hr Inf. 63% 39% 50% 33% Ref. 31 70 pts. V. Push 30mg/kg 52 days Inf. 72% 12% 8% 65% Ref. 32 18 pts. V. Push 27-30mg/kg 4 days Inf. 43% 33% 0% 50% (1) WBC <4000 mmc except Ref. 32 (WBC <3000 mmc) (2) Mucositis, moderate to severe With respect to FUra, there are several substances which can theoretically modulate its activity. metabolic modulations. (I) Chart 2 illustrates three examples of Thymidine (dThd) when administered con- currently with FUra, results in reduction of inhibition of DNA synthesis, due to bypass of FdUMP-inhibited dTMP synthesis.

Download PDF sample

Rated 4.08 of 5 – based on 44 votes