Download A Concise Review of Clinical Laboratory Science, 2nd Edition by Joel David Hubbard, Joel Hubbard PDF

By Joel David Hubbard, Joel Hubbard

The second one version deals a concise evaluation of all parts of medical lab technological know-how, together with the traditional parts, corresponding to hematology, chemistry, hemostasis, immunohematology, medical microbiology, parasitology, urinalysis and extra, in addition to lab administration, lab govt rules, and caliber coverage. A better half site bargains 35 case reviews, a picture financial institution of colour photographs, and a quiz financial institution with 500 questions in certification structure.

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2. Ketoacids are produced by removal of an amino group from an amino acid. Ketoacids can be either: a. Glycogenic to generate glucose precursors; or b. Ketogenic to generate ketone bodies 3. Aminoacidopathies are disorders that involve faulty amino acid metabolism. a. Phenylketonuria (PKU) is an inherited disorder causing lack of phenylalanine hydroxylase and the inability to convert phenylalanine to tyrosine, which results in the formation of phenylpyruvate. PKU causes mental retardation in children.

B. Clinical importance (1) Three porphyrin compounds are clinically important: protoporphyrin (excreted in feces), uroporphyrin (excreted in urine), and coproporphyrin (excreted in both). All are intermediate products in the synthesis of heme that can be assessed clinically. (2) Porphobilinogen (PBG) and ALA are precursors of porphyrin and can accumulate in certain porphyrin disorders. These substances are typically found in the urine of patients with acute porphyria. (3) Free erythrocyte porphyrins (FEP) are porphyrins that can be extracted from RBCs, the primary one being protoporphyrin.

C. Porphyrinuria is a moderate elevation of urine coproporphyrin secondary to a number of disorders, including pregnancy, neoplasia, intoxication, and liver disease. d. Porphyrinemia is a moderate elevation in erythrocyte protoporphyrin secondary to a number of disorders, including: (1) Iron deficiency states, caused by poor nutrition, malabsorption, poor iron transport, or blood loss (2) Anemia (hemolytic, iron-deficiency, sideroblastic) (3) Lead poisoning 3. Methods of porphyrin analysis include qualitative and quantitative procedures.

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